Transient expression of calcium-independent nitric oxide synthase in blood vessels during brain development.

  title={Transient expression of calcium-independent nitric oxide synthase in blood vessels during brain development.},
  author={Elena Galea and Donald J. Reis and Heping Xu and Douglas L Feinstein},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={9 15},
The calcium-independent nitric oxide synthase, known as NOS-II or inducible NOS, is only present in adult brain during pathologies that involve inflammatory events. We sought to establish whether NOS-II was also expressed in the course of normal brain development. NOS-II mRNA, measured by quantitative polymerase chain reaction, appeared during the perinatal period in different brain areas. It was detected on embryonic day 14, the earliest time analyzed, and then levels decayed until the first… CONTINUE READING
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