Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells.

  title={Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells.},
  author={Jun Wang and Andreea Ioan-Facsinay and Ellen I.H. van der Voort and Tom W. J. Huizinga and Ren{\'e} E. M. Toes},
  journal={European journal of immunology},
  volume={37 1},
Foxp3 plays a key role in CD4+ CD25+ T(reg) cell function in mice and represents a specific marker for these cells. Despite the strong association between FOXP3 expression and regulatory function in fresh human T cells, little is known about the dynamics of endogenous FOXP3 expression and its relation to the suppressive function in activated human T cells. Here, we addressed the dynamics of FOXP3 expression during human CD4+ T cell activation by plate-bound anti-CD3 Ab as well as the… CONTINUE READING
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