Transient encephalopathy following high-dose methotrexate treatment in childhood acute lymphoblastic leukemia

Abstract

The purpose of this study was to determine the incidence of and pharmacokinetic parameters associated with the development of transient encephalopathy following the administration of high-dose methotrexate and intrathecal chemotherapy in children with acute lymphoblastic leukemia (ALL). Two hundred and fifty-nine children with newly diagnosed ALL treated on… (More)
DOI: 10.1038/sj.leu.2401098

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