Transient cross-reactive immune responses can orchestrate antigenic variation in malaria

  title={Transient cross-reactive immune responses can orchestrate antigenic variation in malaria},
  author={Mario Recker and Sean Nee and Peter Bull and Samson Kinyanjui and Kevin Marsh and Chris I Newbold and Sunetra Gupta},
The malaria parasite Plasmodium falciparum has evolved to prolong its duration of infection by antigenic variation of a major immune target on the surface of the infected red blood cell. This immune evasion strategy depends on the sequential, rather than simultaneous, appearance of immunologically distinct variants. Although the molecular mechanisms by which a single organism switches between variants are known in part, it remains unclear how an entire population of parasites within the host… 

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  • Biology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1997
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    Proceedings of the Royal Society of London. Series B: Biological Sciences
  • 1999
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