Transient complex I inhibition at the onset of reperfusion by extracellular acidification decreases cardiac injury.

@article{Xu2014TransientCI,
  title={Transient complex I inhibition at the onset of reperfusion by extracellular acidification decreases cardiac injury.},
  author={Aijun Xu and Karol Szczepanek and Michael W Maceyka and Thomas Ro\ss and Elizabeth Bowler and Ying Hu and Barrett P. Kenny and Chris Mehfoud and Pooja N Desai and Clive Marc Baumgarten and Qun Chen and Edward Joseph Lesnefsky},
  journal={American journal of physiology. Cell physiology},
  year={2014},
  volume={306 12},
  pages={C1142-53}
}
A reversible inhibition of mitochondrial respiration by complex I inhibition at the onset of reperfusion decreases injury in buffer-perfused hearts. Administration of acidic reperfusate for a brief period at reperfusion decreases cardiac injury. We asked if acidification treatment decreased cardiac injury during reperfusion by inhibiting complex I. Exposure… CONTINUE READING

7 Figures & Tables

Statistics

010020030020142015201620172018
Citations per Year

293 Citations

Semantic Scholar estimates that this publication has 293 citations based on the available data.

See our FAQ for additional information.