Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation.

@article{Marion2009TransientCI,
  title={Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation.},
  author={Vincent van Marion and Corinne Stoetzel and Dominique Schlicht and Nadia Messaddeq and Michael Koch and Elisabeth Flori and Jean Marc Danse and Jean-Louis Mandel and H{\'e}l{\`e}ne J Dollfus},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 6},
  pages={1820-5}
}
Bardet-Biedl syndrome (BBS) is an inherited ciliopathy generally associated with severe obesity, but the underlying mechanism remains hypothetical and is generally proposed to be of neuroendocrine origin. In this study, we show that while the proliferating preadipocytes or mature adipocytes are nonciliated in culture, a typical primary cilium is present in differentiating preadipocytes. This transient cilium carries receptors for Wnt and Hedgehog pathways, linking this organelle to previously… CONTINUE READING
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