Transient chromatin properties revealed by polymer models and stochastic simulations constructed from Chromosomal Capture data

@inproceedings{Shukron2017TransientCP,
  title={Transient chromatin properties revealed by polymer models and stochastic simulations constructed from Chromosomal Capture data},
  author={Ofir Shukron and David Holcman},
  booktitle={PLoS Computational Biology},
  year={2017}
}
Chromatin organization can be probed by Chromosomal Capture (5C) data, from which the encounter probability (EP) between genomic sites is presented in a large matrix. This matrix is averaged over a large cell population, revealing diagonal blocks called Topological Associating Domains (TADs) that represent a sub-chromatin organization. To study the relation… CONTINUE READING