Transient cell depolarization after permanent middle cerebral artery occlusion: an observation by diffusion-weighted MRI and localized 1H-MRS.

@article{Gyngell1994TransientCD,
  title={Transient cell depolarization after permanent middle cerebral artery occlusion: an observation by diffusion-weighted MRI and localized 1H-MRS.},
  author={Michael Gyngell and Tobias Back and Mathias Hoehn-berlage and Kunio Kohno and K. A. Hossmann},
  journal={Magnetic resonance in medicine},
  year={1994},
  volume={31 3},
  pages={337-41}
}
Focal cerebral ischemia causes rapid intensity changes in diffusion-weighted images (DWI) and elevated lactate as detected by localized proton spectroscopy (1H-MRS). To investigate whether such changes can also be evoked by perischemic depolarizations, we combined DWI and 1H-MRS measurements with DC potential recordings. About 40 min after occlusion of the middle cerebral artery in a rat, a negative DC deflection was observed indicating transient cell depolarization. Coincidentally with the… CONTINUE READING
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