Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways.

@article{Mende1998TransientCE,
  title={Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways.},
  author={U. Mende and A. Kagen and A. Cohen and J. Aramburu and F. Schoen and E. Neer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 23},
  pages={
          13893-8
        }
}
  • U. Mende, A. Kagen, +3 authors E. Neer
  • Published 1998
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • Cardiac hypertrophy and dilatation can result from stimulation of signal transduction pathways mediated by heterotrimeric G proteins, especially Gq, whose alpha subunit activates phospholipase Cbeta (PLCbeta). We now report that transient, modest expression of a hemagglutinin (HA) epitope-tagged, constitutively active mutant of the Gq alpha subunit (HAalpha*q) in hearts of transgenic mice is sufficient to induce cardiac hypertrophy and dilatation that continue to progress after the initiating… CONTINUE READING
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