Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways.

@article{Mende1998TransientCE,
  title={Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways.},
  author={Ulrike Mende and Alexander C. Kagen and Andrew Cohen and Jose Aramburu and Frederick J. Schoen and Eva J. Neer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 23},
  pages={13893-8}
}
Cardiac hypertrophy and dilatation can result from stimulation of signal transduction pathways mediated by heterotrimeric G proteins, especially Gq, whose alpha subunit activates phospholipase Cbeta (PLCbeta). We now report that transient, modest expression of a hemagglutinin (HA) epitope-tagged, constitutively active mutant of the Gq alpha subunit (HAalpha*q) in hearts of transgenic mice is sufficient to induce cardiac hypertrophy and dilatation that continue to progress after the initiating… CONTINUE READING

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Mende et al

  • M. A. Sussman, H. W. Lim, +9 authors 1690–1693. 13898 Medical Sciences
  • Proc. Natl. Acad. Sci. USA 95
  • 1998

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