Transient brain ischemia due to cardiac arrest causes irreversible long-lasting cognitive injury

@article{Kiryk2011TransientBI,
  title={Transient brain ischemia due to cardiac arrest causes irreversible long-lasting cognitive injury},
  author={Anna Kiryk and Ryszard Pluta and Izabela Figiel and Marta Mikosz and Leszek Kaczmarek},
  journal={Behavioural Brain Research},
  year={2011},
  volume={219},
  pages={1-7}
}
Herein, we used a clinically-relevant model of 10 min cardiac arrest (CA) in Wistar rats. Histological analyses of the ischemic brains of old rats showed significant atrophy of CA(1) sector of hippocampus (Nissl and NeuN stainings) corresponding with increase of glial fibrillary acidic protein expression. The long-term behavioral consequences of above manipulation producing global brain ischemia were assessed in young, middle-aged and old rats, i.e., 3-, 6- and 18-months post-treatment… CONTINUE READING

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