Transient blocking of both B7.1 (CD80) and B7.2 (CD86) in addition to CD40–CD40L interaction fully abrogates the immune response following systemic injection of adenovirus vector

@article{Ziller2002TransientBO,
  title={Transient blocking of both B7.1 (CD80) and B7.2 (CD86) in addition to CD40–CD40L interaction fully abrogates the immune response following systemic injection of adenovirus vector},
  author={Christelle Ziller and Fabienne Stoeckel and Louis Boon and H{\'e}l{\`e}ne Haegel-Kronenberger},
  journal={Gene Therapy},
  year={2002},
  volume={9},
  pages={537-546}
}
Blockade of the CD40–CD40L and CD80/CD86–CD28 costimulatory pathways represents a strategy to inhibit the immune response against Ad vectors designed for gene therapy applications. Since most previous studies have used a CTLA4-Ig fusion molecule binding to both CD80 and CD86, the respective roles of these B7 molecules remained undefined. We have studied the effect of blocking monoclonal Abs (mAbs) directed against the costimulatory molecules CD40L, CD80 and CD86, alone or in different… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Intravenous administration of an E1/E3-deleted adenoviral vector induces tolerance to factor IX in C57Bl/6 mice

  • PA Fields
  • Gene Therapy
  • 2001

Similar Papers

Loading similar papers…