Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

Abstract

The mechanism by which the proapoptotic Bcl-2 family members Bax and Bak release cytochrome c from mitochondria is incompletely understood. In this paper, we show that activator BH3-only proteins bind tightly but transiently to the Bak hydrophobic BH3-binding groove to induce Bak oligomerization, liposome permeabilization, mitochondrial cytochrome c release… (More)
DOI: 10.1083/jcb.201102027

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