Transient binding and dissipation in cross-linked actin networks.


In contrast with entangled actin solutions, transiently cross-linked actin networks can provide highly elastic properties while still allowing for local rearrangements in the microstructure-on biological relevant time scales. Here, we show that thermal unbinding of transient cross-links entails local stress relaxation and energy dissipation in an intermediate elasticity dominated frequency regime. We quantify the viscoelastic response of an isotropically cross-linked actin network by experimentally tuning the off rate of the transiently cross-linking molecules, their density, and the solvent viscosity. We reproduce the measured frequency response by a semiphenomenological model that is predicated on microscopic unbinding events.

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@article{Lieleg2008TransientBA, title={Transient binding and dissipation in cross-linked actin networks.}, author={Oliver Lieleg and Mireille M. A. E. Claessens and Yiliang Luan and Andreas R. Bausch}, journal={Physical review letters}, year={2008}, volume={101 10}, pages={108101} }