Transient beta adrenergic stimulation can precondition the rat heart against postischaemic contractile dysfunction.

@article{Asimakis1994TransientBA,
  title={Transient beta adrenergic stimulation can precondition the rat heart against postischaemic contractile dysfunction.},
  author={Gregory K. Asimakis and K Inners-McBride and Vincent R. Conti and C. J. Yang},
  journal={Cardiovascular research},
  year={1994},
  volume={28 11},
  pages={
          1726-34
        }
}
OBJECTIVE The aim was to assess the abilities of exogenous noradrenaline, isoprenaline, and phenylephrine to precondition the isolated rat heart against ischaemic and reperfusion injury. METHODS The isovolumetric Langendorff rat heart model was used to determine postischaemic recovery of left ventricular function. The hearts were subjected to 30 min of normothermic global ischaemia followed by 30 min reperfusion. Treated hearts were perfused with noradrenaline (10(-7) M), isoprenaline (10(-8… CONTINUE READING

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