Transient antiislet autoantibodies: infrequent occurrence and lack of association with "genetic" risk factors.

@article{Yu2000TransientAA,
  title={Transient antiislet autoantibodies: infrequent occurrence and lack of association with "genetic" risk factors.},
  author={Jaejun Yu and Liping Yu and Teodorica L. Bugawan and Henry A. Erlich and Katherine J. Barriga and Michelle R Hoffman and Marian Rewers and George S. Eisenbarth},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2000},
  volume={85 7},
  pages={2421-8}
}
We hypothesized that genetic determinants of expression of persistent antiislet autoantibodies would similarly influence the expression of transient autoantibodies. To test this hypothesis, we prospectively evaluated sera from 478 relatives (SOC: sibling-offspring cohort) of patients with type 1 diabetes as well as 793 newborns from the general population (NEC: newborn nonrelative cohort) selected for expression of specific human leukocyte antigen haplotypes. Eight relatives of 478 (1.7% of SOC… CONTINUE READING
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