Transient antibody-mucin interactions produce a dynamic molecular shield against viral invasion.

Abstract

Given the difficulty in finding a cure for HIV/AIDS, a promising prevention strategy to reduce HIV transmission is to directly block infection at the portal of entry. The recent Thai RV144 trial offered the first evidence that an antibody-based vaccine may block heterosexual HIV transmission. Unfortunately, the underlying mechanism(s) for protection remain… (More)
DOI: 10.1016/j.bpj.2014.02.038

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6 Figures and Tables