Transient and controllable opening of the blood-brain barrier to cytostatic and antibiotic agents by alkylglycerols in rats

Abstract

The blood-brain barrier hinders progress in the chemotherapy of brain tumors due to insufficient penetration of anticancer drugs into the brain tissue. Short-chain alkylglycerols affect the physicochemical properties of biological membranes. The enhancement of the blood-brain barrier permeability by intra-arterial administration of alkylglycerols was… (More)
DOI: 10.1007/s002210000553

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