Transient and constitutive repression of cytoplasmic translation signaling in cells with mtDNA mutation


Cytoplasmic translation is under sophisticated control but how cells adapt its rate to constitutive loss of mitochondrial oxidative phosphorylation is unknown. Here we show that translation is repressed in cells with the pathogenic A3243G mtDNA mutation or in mtDNA-less ρ0 cells by at least two distinct pathways, one transiently targeting elongation factor… (More)
DOI: 10.1007/s00018-009-8687-4


10 Figures and Tables

Slides referencing similar topics