Transient and Persistent Dendritic Spines in the Neocortex In Vivo

@article{Holtmaat2005TransientAP,
  title={Transient and Persistent Dendritic Spines in the Neocortex In Vivo},
  author={Anthony J.G.D. Holtmaat and Joshua T. Trachtenberg and Linda Wilbrecht and Gordon M. G. Shepherd and Xiaoqun Zhang and Graham Knott and Karel Svoboda},
  journal={Neuron},
  year={2005},
  volume={45},
  pages={279-291}
}
Dendritic spines were imaged over days to months in the apical tufts of neocortical pyramidal neurons (layers 5 and 2/3) in vivo. A fraction of thin spines appeared and disappeared over a few days, while most thick spines persisted for months. In the somatosensory cortex, from postnatal day (PND) 16 to PND 25 spine retractions exceeded additions, resulting in a net loss of spines. The fraction of persistent spines (lifetime > or = 8 days) grew gradually during development and into adulthood… CONTINUE READING
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