Transient alteration of T cell fine specificity by a strong primary stimulus correlates with T cell receptor down-regulation.

@article{Martin1998TransientAO,
  title={Transient alteration of T cell fine specificity by a strong primary stimulus correlates with T cell receptor down-regulation.},
  author={S M Martin and Michael Arthur John Bevan},
  journal={European journal of immunology},
  year={1998},
  volume={28 10},
  pages={
          2991-3002
        }
}
P14 mice expressing a transgenic TCR specific for the lymphocytic choriomeningitis virus glycoprotein p33 epitope were used to study the induction of CTL effector activity by a variety of ligands. Surprisingly, p33 variants which are weaker agonists for the P14 TCR than the wild-type p33 peptide were able to induce more potent effectors with a broader range of cytolytic specificity. Similarly, low concentrations of p33 were more effective than higher concentrations. These results correlated… CONTINUE READING

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