Transient activation of calcium-dependent phospholipase A2 by insulin secretagogues in isolated pancreatic islets.

@article{Jolly1993TransientAO,
  title={Transient activation of calcium-dependent phospholipase A2 by insulin secretagogues in isolated pancreatic islets.},
  author={Yannick Jolly and Christopher D Major and Bryan A. Wolf},
  journal={Biochemistry},
  year={1993},
  volume={32 45},
  pages={
          12209-17
        }
}
Arachidonic acid is believed to be an important and necessary mediator of insulin secretion by beta-cells of islets of Langerhans, and it may regulate intracellular Ca2+ homeostasis. Insulin secretagogues, such as glucose and the muscarinic agonist carbachol, stimulate arachidonic acid accumulation, although the mechanisms involved are controversial: carbachol is believed to stimulate phospholipase A2, while glucose-induced arachidonic acid release is the result of diacylglycerol hydrolysis… Expand
Involvement of phospholipase A2 and arachidonic acid in cholecystokinin-8-induced insulin secretion in rat islets
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It is concluded that CCK-8-induced insulin secretion is partially mediated by a pathway involving PLA2, and that the formed AA, rather than its metabolites, is of importance. Expand
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  • M. Dunlop, S. Clark
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  • The international journal of biochemistry & cell biology
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It could be shown that phosphorylation of immunoprecipitated phospholipase A2 was augmented by prolonged glucose exposure (> 1 hr) in a protein kinase C-dependent manner. Expand
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The cAMP-PKA pathway restrains both Ca( 2+)-dependent and Ca(2+)-independent PLA(2) activation, indicating a regulating crosstalk between these two pathways. Expand
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TLDR
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TLDR
It is suggested that RHC 80267 and ACA, independently of their action on AA release, may inhibit glucose-induced insulin secretion by the opening of ATP-sensitive K+ channels in islets. Expand
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