Transient Tissue-Scale Deformation Coordinates Alignment of Planar Cell Polarity Junctions in the Mammalian Skin

@article{Aw2016TransientTD,
  title={Transient Tissue-Scale Deformation Coordinates Alignment of Planar Cell Polarity Junctions in the Mammalian Skin},
  author={Wen Yih Aw and Bryan W. Heck and Bradley R. Joyce and Danelle Devenport},
  journal={Current Biology},
  year={2016},
  volume={26},
  pages={2090-2100}
}
Planar cell polarity (PCP) refers to the collective alignment of polarity along the tissue plane. In skin, the largest mammalian organ, PCP aligns over extremely long distances, but the global cues that orient tissue polarity are unknown. Here, we show that Celsr1 asymmetry arises concomitant with a gradient of tissue deformation oriented along the medial-lateral axis. This uniaxial tissue tension, whose origin remains unknown, transiently transforms basal epithelial cells from initially… CONTINUE READING
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