Transient Suppression of TGFβ Receptor Signaling Facilitates Human Islet Transplantation.

Abstract

Although islet transplantation is an effective treatment for severe diabetes, its broad application is greatly limited due to a shortage of donor islets. Suppression of TGFβ receptor signaling in β-cells has been shown to increase β-cell proliferation in mice, but has not been rigorously examined in humans. Here, treatment of human islets with a TGF… (More)
DOI: 10.1210/en.2015-1986

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