Transient Suppression of TGFβ Receptor Signaling Facilitates Human Islet Transplantation.

@article{Xiao2016TransientSO,
  title={Transient Suppression of TGFβ Receptor Signaling Facilitates Human Islet Transplantation.},
  author={Xiangwei Xiao and Shane Fischbach and Zewen Song and Iljana Gaffar and Ray Zimmerman and John Wiersch and Krishna L Prasadan and Chiyo Shiota and Ping Guo and Sabarinathan Ramachandran and Piotr Witkowski and George K. Gittes},
  journal={Endocrinology},
  year={2016},
  volume={157 4},
  pages={
          1348-56
        }
}
Although islet transplantation is an effective treatment for severe diabetes, its broad application is greatly limited due to a shortage of donor islets. Suppression of TGFβ receptor signaling in β-cells has been shown to increase β-cell proliferation in mice, but has not been rigorously examined in humans. Here, treatment of human islets with a TGFβ receptor I inhibitor, SB-431542 (SB), significantly improved C-peptide secretion by β-cells, and significantly increased β-cell number by… CONTINUE READING

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