Transient Resolution of Treatment-Resistant Posttraumatic Stress Disorder Following Ketamine Infusion

  title={Transient Resolution of Treatment-Resistant Posttraumatic Stress Disorder Following Ketamine Infusion},
  author={Daniel D’Andrea and Richard Andrew Sewell},
  journal={Biological Psychiatry},

Subanesthetic Dose Ketamine in Posttraumatic Stress Disorder: A Role for Reconsolidation During Trauma-Focused Psychotherapy?

It is explored whether single intravenous infusion of a subanesthetic dose of ketamine can be considered as a viable augmentation strategy for trauma-focused psychotherapy in patients with PTSD and five additional topics that need to be addressed concerning the psychotherapeutic approach and phase orientation of pharmacological assisted psychotherapy.

Low Dose Ketamine Infusion for Comorbid Posttraumatic Stress Disorder and Chronic Pain: A Randomized Double-Blind Clinical Trial

This first prospective study comparing effects of subanesthetic ketamine versus ketorolac infusions for comorbid PTSD and CP, suggests that both ketamine and ket orolac might offer meaningful and durable response for both PTSD andCP symptoms.

Augmenting the Treatment of PTSD with Ketamine—a Review

Based on animal and human research on fear extinction and memory reconsolidation, neurobiological changes that emerge following a ketamine infusion can enhance learning and thus benefit exposure-based psychotherapies for PTSD.

Has psychiatry tamed the “ketamine tiger?” Considerations on its use for depression and anxiety

  • K. Rasmussen
  • Psychology, Biology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2016

Investigational drugs under development for the treatment of PTSD

There appears to be a promise in drugs as cognitive enhancers, the use of drug cocktails and novel compounds that target specific pathways linked to the etiology of PTSD.

Subanesthetic-Dose Ketamine to Decrease Emergence Delirium in the Surgical Patient With Posttraumatic Stress Disorder.

By appreciating the relationship that exists between ED, PTSD, and glutamate, one can extrapolate that a subanesthetic dose of ketamine may decrease ED in the surgical patient with PTSD.



Effects of peritraumatic ketamine medication on early and sustained posttraumatic stress symptoms in moderately injured accident victims

The data provide first evidence for a modulating effect of a single-dose ketamine on the severity and duration of posttraumatic stress symptoms in accident victims.

Ketamine as a Rapid Treatment for Post-Traumatic Stress Disorder

Abstract : Post-traumatic stress disorder (PTSD) is a debilitating anxiety disorder characterized by intrusive re-experiencing of the traumatic events, avoidance of situations and stimuli that could

Ketamine for the treatment of depression.

  • R. Howland
  • Psychology, Medicine
    Journal of psychosocial nursing and mental health services
  • 2013
Although the effectiveness of alternative routes of ketamine administration needs to be determined, intravenous ketamine could be conceptualized as a clinic-based procedural therapy for treatment resistant forms of depression.

The correlation between ketamine and posttraumatic stress disorder in burned service members.

Patients receiving perioperative ketamine had a lower prevalence of PTSD than soldiers receiving no ketamine during their surgeries despite having larger burns, higher injury severity score, undergoing more operations, and spending more time in the ICU.

Antidepressant effects of ketamine in depressed patients

Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression

Potentiation of Low Dose Ketamine Effects by Naltrexone: Potential Implications for the Pharmacotherapy of Alcoholism

The data suggest that the interplay of opiate receptor antagonism and NMDA receptors antagonism may be relevant to the protective effects of naltrexone on alcohol consumption via potentiation of dysphoric effects associated with the NMDA receptor antagonist effects of ethanol.

Ketamine aggravates symptoms of acute stress disorder in a naturalistic sample of accident victims

Whether ketamine administration after moderate accidental trauma modulates dissociation and other symptoms of acute stress disorder (ASD) in the direct aftermath of the event was examined and there were significant associations between ketamine analgosedation and increased symptoms of dissociation, reexperiencing, hyperarousal and avoidance relative to the comparison groups.