Transient Receptor Potential Vanilloid 4 and Serum Glucocorticoid-regulated Kinase 1 Are Critical Mediators of Lung Injury in Overventilated Mice In Vivo.

@article{Michalick2017TransientRP,
  title={Transient Receptor Potential Vanilloid 4 and Serum Glucocorticoid-regulated Kinase 1 Are Critical Mediators of Lung Injury in Overventilated Mice In Vivo.},
  author={Laura Michalick and Lasti Erfinanda and Ulrike Weichelt and Markus van der Giet and Wolfgang Liedtke and Wolfgang M. Kuebler},
  journal={Anesthesiology},
  year={2017},
  volume={126 2},
  pages={
          300-311
        }
}
BACKGROUND Mechanical ventilation can cause lung endothelial barrier failure and inflammation cumulating in ventilator-induced lung injury. Yet, underlying mechanotransduction mechanisms remain unclear. Here, the authors tested the hypothesis that activation of the mechanosensitive Ca channel transient receptor potential vanilloid (TRPV4) by serum glucocorticoid-regulated kinase (SGK) 1 may drive the development of ventilator-induced lung injury. METHODS Mice (total n = 54) were ventilated… CONTINUE READING
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