Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury

@article{Hurt2016TransientRP,
  title={Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury},
  author={Carl M. Hurt and Yao Lu and Creed M. Stary and Honit Piplani and Bryce A. Small and Travis J. Urban and Nir Qvit and Garrett Gross and Daria Mochly-Rosen and Eric R Gross},
  journal={Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease},
  year={2016},
  volume={5}
}
  • Carl M. Hurt, Yao Lu, +7 authors Eric R Gross
  • Published 2016
  • Medicine
  • Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
  • BACKGROUND The transient receptor potential vanilloid 1 (TRPV1) mediates cellular responses to pain, heat, or noxious stimuli by calcium influx; however, the cellular localization and function of TRPV1 in the cardiomyocyte is largely unknown. We studied whether myocardial injury is regulated by TRPV1 and whether we could mitigate reperfusion injury by limiting the calcineurin interaction with TRPV1. METHODS AND RESULTS In primary cardiomyocytes, confocal and electron microscopy demonstrates… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 55 REFERENCES

    12-Lipoxygenase-derived eicosanoids protect against myocardial ischemia/reperfusion injury via activation of neuronal TRPV1.

    VIEW 1 EXCERPT

    Regulation of TRPV1 by a novel renally expressed rat TRPV1 splice variant.

    VIEW 1 EXCERPT