Transient Receptor Potential Channel Opening Releases Endogenous Acetylcholine, which Contributes to Endothelium-Dependent Relaxation Induced by Mild Hypothermia in Spontaneously Hypertensive Rat but Not Wistar-Kyoto Rat Arteries.

@article{Zou2015TransientRP,
  title={Transient Receptor Potential Channel Opening Releases Endogenous Acetylcholine, which Contributes to Endothelium-Dependent Relaxation Induced by Mild Hypothermia in Spontaneously Hypertensive Rat but Not Wistar-Kyoto Rat Arteries.},
  author={Q. Zou and Susan W S Leung and Paul M. Vanhoutte},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2015},
  volume={354 2},
  pages={
          121-30
        }
}
  • Q. Zou, Susan W S Leung, Paul M. Vanhoutte
  • Published in
    The Journal of pharmacology…
    2015
  • Medicine, Chemistry
  • Mild hypothermia causes endothelium-dependent relaxations, which are reduced by the muscarinic receptor antagonist atropine. The present study investigated whether endothelial endogenous acetylcholine contributes to these relaxations. Aortic rings of spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats were contracted with prostaglandin F2 α and exposed to progressive mild hypothermia (from 37 to 31°C). Hypothermia induced endothelium-dependent, Nω-nitro-l-arginine… CONTINUE READING

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