Transient P-cadherin expression in radiation proctitis; a model of mucosal injury and repair.

@article{Hardy2002TransientPE,
  title={Transient P-cadherin expression in radiation proctitis; a model of mucosal injury and repair.},
  author={Robert Hardy and Rachel Mary Brown and Sarah J Miller and Chris Tselepis and Dion G. Morton and Janusz A Z Jankowski and D Scott A Sanders},
  journal={The Journal of pathology},
  year={2002},
  volume={197 2},
  pages={194-200}
}
Morphology at both cellular and glandular levels in the colon is dependent to an extent on cell-cell adhesion mediated by cadherin-catenin complexes. Alterations in the expression of E-cadherin, the cadherin normally present in colon, have been shown to be implicated in tissue remodelling within the gastrointestinal tract. Furthermore, it has previously been shown that P-cadherin, normally present only in stratified epithelia and placenta, is expressed in colitis and during neoplastic change in… CONTINUE READING