Transient Optoplasmonic Detection of Single Proteins with Sub-Microsecond Resolution

@inproceedings{Baaske2021TransientOD,
  title={Transient Optoplasmonic Detection of Single Proteins with Sub-Microsecond Resolution},
  author={Martin Dieter Baaske and Nazli Asgari and Deep Punj and Michel Orrit},
  year={2021}
}
Optoplasmonic methods capable of single protein detection so far rely on analyte immobilization in order to facilitate detection [1-6]. These detection schemes, even if they facilitate transient single-molecule detection [7,8] via consequent formation and cleavage of chemical bonds, typically exhibit time resolutions on the order of milliseconds. The need for analyte immobilisation is a direct consequence of the minuscule dimensions of plasmonic near fields typically providing sub-attolitre… 
2 Citations

Label-Free Imaging of Single Proteins and Binding Kinetics Using Total Internal Reflection-Based Evanescent Scattering Microscopy.

Single-molecule detection can push beyond ensemble averages and reveal the statistical distributions of molecular properties. Measuring the binding kinetics of single proteins also represents one of

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