Transient Maternal IL-6 boosts glutamatergic synapses and disrupts hippocampal connectivity in the offspring

  title={Transient Maternal IL-6 boosts glutamatergic synapses and disrupts hippocampal connectivity in the offspring},
  author={Filippo Mirabella and Genni Desiato and Sara Mancinelli and Giuliana Fossati and Marco Rasile and Raffaella Morini and Marija Markicevic and Christina Grimm and Clara A Amegandjin and Alberto Termanini and Clelia Peano and Paolo Kunderfranco and Graziella Di Cristo and Valerio Zerbi and Simona Lodato and Elisabetta Menna and Michela Matteoli and Davide Pozzi},
Early prenatal inflammatory conditions are thought to represent a risk factor for different neurodevelopmental disorders, with long-term consequences on adult brain connectivity. Here we show that a transient IL-6 elevation, occurring at vulnerable stages of early neurodevelopment, directly impacts brain developmental trajectories through the aberrant enhancement of glutamatergic synapses and overall brain hyper-connectivity. The IL6-mediated boost of excitatory synapse density results from the… Expand
2 Citations
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