Transient Inhibition of Histone Deacetylation Alters the Structural and Functional Imprint at Fission Yeast Centromeres

@article{Ekwall1997TransientIO,
  title={Transient Inhibition of Histone Deacetylation Alters the Structural and Functional Imprint at Fission Yeast Centromeres},
  author={Karl Ekwall and Tim G. S. Olsson and Bryan M. Turner and Gwen Cranston and Robin C. Allshire},
  journal={Cell},
  year={1997},
  volume={91},
  pages={1021-1032}
}
Histone acetylation may act to mark and maintain transcriptionally active or inactive chromosomal domains through the cell cycle and in different lineages. A novel role for histone acetylation in centromere regulation has been identified. Exposure of fission yeast cells to TSA, a specific inhibitor of histone deacetylase, interferes with repression of marker genes in centromeric heterochromatin, causes chromosome loss, and disrupts the localization of Swi6p, a component of centromeric… CONTINUE READING
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The case for epigenetic effects on centromere identity and function

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