Transient Increase in Zn2+ in Hippocampal CA1 Pyramidal Neurons Causes Reversible Memory Deficit

@inproceedings{Takeda2011TransientII,
  title={Transient Increase in Zn2+ in Hippocampal CA1 Pyramidal Neurons Causes Reversible Memory Deficit},
  author={Atsushi Takeda and Shunsuke Takada and Masatoshi Nakamura and Miki Suzuki and Haruna Tamano and Masaki Ando and Naoto Oku},
  booktitle={PloS one},
  year={2011}
}
The translocation of synaptic Zn(2+) to the cytosolic compartment has been studied to understand Zn(2+) neurotoxicity in neurological diseases. However, it is unknown whether the moderate increase in Zn(2+) in the cytosolic compartment affects memory processing in the hippocampus. In the present study, the moderate increase in cytosolic Zn(2+) in the hippocampus was induced with clioquinol (CQ), a zinc ionophore. Zn(2+) delivery by Zn-CQ transiently attenuated CA1 long-term potentiation (LTP… CONTINUE READING
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