Transient Focal Cerebral Ischemia Down-Regulates Glutamate Transporters GLT-1 and EAAC1 Expression in Rat Brain

@article{Rao2001TransientFC,
  title={Transient Focal Cerebral Ischemia Down-Regulates Glutamate Transporters GLT-1 and EAAC1 Expression in Rat Brain},
  author={Vemuganti L. Raghavendra Rao and Kellie K. Bowen and Robert J Dempsey},
  journal={Neurochemical Research},
  year={2001},
  volume={26},
  pages={497-502}
}
Transient focal cerebral ischemia leads to extensive excitotoxic neuronal damage in rat cerebral cortex. Efficient reuptake of the released glutamate is essential for preventing glutamate receptor over-stimulation and neuronal death. Present study evaluated the expression of the glial (GLT-1 and GLAST) and neuronal (EAAC1) subtypes of glutamate transporters after transient middle cerebral artery occlusion (MCAO) induced focal cerebral ischemia in rats. Between 24h to 72h of reperfusion after… CONTINUE READING