Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin

@inproceedings{Lewis2009TransientFN,
  title={Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin},
  author={David J Lewis and Zhiming Huo and Susan J. Barnett and Ingrid Kromann and Rafaela Giemza and Eva P Galiza and Maria Woodrow and Birgit Thierry-Carstensen and Peter Hvilsh\oj Andersen and Deborah L. Novicki and Giuseppe Del Giudice and Rino Rappuoli},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND An association was previously established between facial nerve paralysis (Bell's palsy) and intranasal administration of an inactivated influenza virosome vaccine containing an enzymatically active Escherichia coli Heat Labile Toxin (LT) adjuvant. The individual component(s) responsible for paralysis were not identified, and the vaccine was withdrawn. METHODOLOGY/PRINCIPAL FINDINGS Subjects participating in two contemporaneous non-randomized Phase 1 clinical trials of nasal subunit… CONTINUE READING
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