Transient Down-Regulation of Nucleoside Transporter 3 Gene Expression as a Drug Target in Leishmania major Using Antisense RNA Technology

@inproceedings{Tohidi2019TransientDO,
  title={Transient Down-Regulation of Nucleoside Transporter 3 Gene Expression as a Drug Target in Leishmania major Using Antisense RNA Technology},
  author={Farideh Tohidi and Bahram Kazemi and Mojgan Bandehpour and Iraj Sharifi and Mohammad Reza Rabiei and Ebrahim Saedi Dezaki and Zahra Babaei},
  booktitle={Iranian journal of parasitology},
  year={2019}
}
Background This study was aimed to silencing the Nucleoside transporter 3 (NT3) permease nucleobases involved in the salvage pathway of Leishmania in order to disrupt purine nucleotide uptake in the parasite and consequently, destruction of the parasite. Methods Overall, 502 bp fragment of the NT3 gene sequence was designed to produce an antisense transcript upon entry of the vector into the parasite. The NT3 construct was transfected into L. major promastigotes and NT3 gene expression was… CONTINUE READING

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