Transient Ca2+ depletion of the sarcoplasmic reticulum at the onset of reperfusion.

@article{Valverde2010TransientCD,
  title={Transient Ca2+ depletion of the sarcoplasmic reticulum at the onset of reperfusion.},
  author={Carlos A. Valverde and Dmytro Kornyeyev and Marcela Ferreiro and Azad{\'e} D. Petrosky and Alicia R. Mattiazzi and A. L. Escobar},
  journal={Cardiovascular research},
  year={2010},
  volume={85 4},
  pages={671-80}
}
AIMS Myocardial stunning is a contractile dysfunction that occurs after a brief ischaemic insult. Substantial evidence supports that this dysfunction is triggered by Ca2+ overload during reperfusion. The aim of the present manuscript is to define the origin of this Ca2+ increase in the intact heart. METHODS AND RESULTS To address this issue, Langendorff-perfused mouse hearts positioned on a pulsed local field fluorescence microscope and loaded with fluorescent dyes Rhod-2, Mag-fluo-4, and Di… CONTINUE READING