Transient Activation of Hematopoietic Stem and Progenitor Cells by IFNγ during Acute Bacterial Infection

@article{MacNamara2011TransientAO,
  title={Transient Activation of Hematopoietic Stem and Progenitor Cells by IFN$\gamma$ during Acute Bacterial Infection},
  author={K. MacNamara and Maura Jones and Olga Martin and G. Winslow},
  journal={PLoS ONE},
  year={2011},
  volume={6}
}
How hematopoietic stem cells (HSCs) respond to inflammatory signals during infections is not well understood. Our studies have used a murine model of ehrlichiosis, an emerging tick-born disease, to address how infection impacts hematopoietic function. Infection of C57BL/6 mice with the intracellular bacterium, Ehrlichia muris, results in anemia and thrombocytopenia, similar to what is observed in human ehrlichiosis patients. In the mouse, infection promotes myelopoiesis, a process that is… Expand
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