Transglutaminases factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.

@article{Mousa2017TransglutaminasesFX,
  title={Transglutaminases factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.},
  author={Aisha Mousa and Cui Cui and Aimei Song and Vamsee D. Myneni and Huifang Sun and Jin Jin Li and Monzur Murshed and Gerry Melino and Mari T Kaartinen},
  journal={Cell death and differentiation},
  year={2017},
  volume={24 5},
  pages={844-854}
}
Appropriate bone mass is maintained by bone-forming osteoblast and bone-resorbing osteoclasts. Mesenchymal stem cell (MSC) lineage cells control osteoclastogenesis via expression of RANKL and OPG (receptor activator of nuclear factor κB ligand and osteoprotegerin), which promote and inhibit bone resorption, respectively. Protein crosslinking enzymes transglutaminase 2 (TG2) and Factor XIII-A (FXIII-A) have been linked to activity of myeloid and MSC lineage cells; however, in vivo evidence has… CONTINUE READING
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