Transglutaminases: multifunctional cross‐linking enzymes that stabilize tissues

@article{Greenberg1991TransglutaminasesMC,
  title={Transglutaminases: multifunctional cross‐linking enzymes that stabilize tissues},
  author={Charles S. Greenberg and Paul J. Birckbichler and Robert H. Rice},
  journal={The FASEB Journal},
  year={1991},
  volume={5},
  pages={3071 - 3077}
}
Transglutaminases catalyze the posttranslational modification of proteins by transamidation of available glutamine residues. This action results primarily in the formation of ∊‐(γ‐glutamyl)lysine cross‐links but includes the incorporation of polyamines into suitable protein substrates as well. The covalent isopeptide crosslink is stable and resistant to proteolysis, thereby increasing the resistance of tissue to chemical, enzymatic, and mechanical disruption. The plasma transglutaminase, factor… 
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