Transglutaminase transcription and antigen translocation in experimental renal scarring.

  title={Transglutaminase transcription and antigen translocation in experimental renal scarring.},
  author={T. Sudhakar Johnson and Nicholas James Skill and Abdel Meguid El Nahas and Simon D Oldroyd and Graham L. Thomas and Jennie A Douthwaite and John Haylor and M. F. Griffin},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={10 10},
It was recently demonstrated that renal tissue transglutaminase (tTg) protein and its catalytic product the epsilon(gamma-glutamyl) lysine protein cross-link are significantly increased in the subtotal (5/6) nephrectomy model (SNx) of renal fibrosis in rats. It was proposed that the enzyme had two important physiologic functions in disease development; one of stabilizing the increased extracellular matrix (ECM) by protein cross-linking, the other in a novel form of tubular cell death. This… CONTINUE READING
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