Transglutaminase inhibition by 2-[(2-oxopropyl)thio]imidazolium derivatives: mechanism of factor XIIIa inactivation.

@article{Freund1994TransglutaminaseIB,
  title={Transglutaminase inhibition by 2-[(2-oxopropyl)thio]imidazolium derivatives: mechanism of factor XIIIa inactivation.},
  author={K F Freund and K P Doshi and Stanley L. Gaul and David A. Claremon and Dr. Christian R{\'e}my and John J. Baldwin and Steven M. Pitzenberger and Andrew M Stern},
  journal={Biochemistry},
  year={1994},
  volume={33 33},
  pages={10109-19}
}
The physiologic role of several transglutaminases could be more precisely defined with the development of specific inhibitors for these enzymes. In addition, specific plasma transglutaminase (fXIIIa) inhibitors may have therapeutic utility in the treatment of thrombosis. For these purposes, the inactivation of fXIIIa and human erythrocyte transglutaminase (HET) by 2-[(2-oxopropyl)thio]imidazolium derivatives, which comprise a novel class of transglutaminase inactivators, was studied. As a… CONTINUE READING