Transglutaminase diseases: from biochemistry to the bedside

@article{Lorand2019TransglutaminaseDF,
  title={Transglutaminase diseases: from biochemistry to the bedside},
  author={Laszlo Lorand and Siiri E. Iismaa},
  journal={The FASEB Journal},
  year={2019},
  volume={33},
  pages={12 - 3}
}
In humans, 9 members of the transglutaminase (TG) family have been identified, of which 8 [factor XIII (FXIII)A and TG1–TG7] catalyze post‐translational protein‐modifying reactions, and 1 does not (protein 4.2). The TG enzymatic activities considered in our discussion of human disease include deamidation of glutamine (Gln) residues, amine incorporation into Gln residues, and protein crosslinking. Except for TG7, which remains poorly studied, all individual TG members have been correlated with… Expand
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