Transglutaminase and diseases of the central nervous system.


Alzheimer's disease, Parkinson's disease and diseases of expanded polyglutamine are associated with insoluble protein aggregates and neuronal death. A role for transglutaminase in the stabilization of these aggregates has been proposed. Diseases of polyglutamine expansion have been the most thoroughly investigated and a large body of studies supports the causative role of transglutaminase in aggregation of expanded polyglutamine. However none of the evidence is conclusive. Indisputable evidence of cross-linking by transglutaminase will be required in order to provide firm support for therapeutic measures based on the role of transglutaminase.

Cite this paper

@article{Hoffner2005TransglutaminaseAD, title={Transglutaminase and diseases of the central nervous system.}, author={Guylaine Hoffner and Philippe Djian}, journal={Frontiers in bioscience : a journal and virtual library}, year={2005}, volume={10}, pages={3078-92} }