Transglutaminase and coeliac disease: endomysial reactivity and small bowel expression.

  title={Transglutaminase and coeliac disease: endomysial reactivity and small bowel expression.},
  author={Giovanna Brusco and Paola Muzi and Rachele Ciccocioppo and Federico Biagi and Maria Grazia Cifone and Gino R Corazza},
  journal={Clinical and experimental immunology},
  volume={118 3},
This study was aimed at verifying whether tissue transglutaminase (tTG) is the sole autoantigen eliciting anti-endomysial antibodies in coeliac disease (CoD) and investigating tTG expression in normal and coeliac mucosa. Twelve anti-endomysial-positive coeliac sera and 12 anti-endomysial-negative control sera (10 microl, diluted 1:5-1:400 in PBS pH 7.3) were preincubated with 10, 20 or 50 microg guinea pig liver tTG at 4 degrees C overnight. Monkey oesophagus tissue slides were then tested with… CONTINUE READING


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