Transglutaminase activity regulates differentiation, migration and fusion of osteoclasts via affecting actin dynamics.

@article{Sun2018TransglutaminaseAR,
  title={Transglutaminase activity regulates differentiation, migration and fusion of osteoclasts via affecting actin dynamics.},
  author={Huifang Sun and Mari T Kaartinen},
  journal={Journal of cellular physiology},
  year={2018},
  volume={233 9},
  pages={
          7497-7513
        }
}
Osteoclasts, bone resorbing cells, derive from monocyte/macrophage cell lineage. Increased osteoclast activity is responsible for bone destruction in diseases such as osteoporosis, periodontitis and rheumatoid arthritis. Transglutaminases (TGs), protein crosslinking enzymes, were recently found involved in osteoclastogenesis in vivo, however their… CONTINUE READING