Transglutaminase activity is increased in Alzheimer's disease brain.

  title={Transglutaminase activity is increased in Alzheimer's disease brain.},
  author={Gail V W Johnson and Thimoty M Cox and Jane Lockhart and M D Zinnerman and Martin S. Miller and Robert E. Powers},
  journal={Brain research},
  volume={751 2},
Transglutaminase is a calcium-activated enzyme that crosslinks substrate proteins into insoluble, often filamentous aggregates resistant to proteases. Because the neurofibrillary tangles in Alzheimer's disease have similar characteristics, and because tau protein, the major component of these tangles is an excellent substrate of transglutaminase in vitro, transglutaminase activity and levels were measured in control and Alzheimer's disease brain. Frozen prefrontal cortex and cerebellum samples… CONTINUE READING