Transglutaminase 2 takes center stage as a cancer cell survival factor and therapy target

@article{Eckert2019Transglutaminase2T,
  title={Transglutaminase 2 takes center stage as a cancer cell survival factor and therapy target},
  author={Richard L. Eckert},
  journal={Molecular Carcinogenesis},
  year={2019},
  volume={58},
  pages={837 - 853}
}
  • R. Eckert
  • Published 2019
  • Biology, Medicine
  • Molecular Carcinogenesis
Transglutaminase 2 (TG2) has emerged as a key cancer cell survival factor that drives epithelial to mesenchymal transition, angiogenesis, metastasis, inflammation, drug resistance, cancer stem cell survival and stemness, and invasion and migration. TG2 can exist in a GTP‐bound signaling‐active conformation or in a transamidase‐active conformation. The GTP bound conformation of TG2 contributes to cell survival and the transamidase conformation can contribute to cell survival or death. We present… Expand
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The Biological and Biomechanical Role of Transglutaminase-2 in the Tumour Microenvironment
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The role of transglutaminase 2 in mediating glial cell function and pathophysiology in the central nervous system.
TLDR
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TLDR
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High‐risk endometrial cancer proteomic profiling reveals that FBXW7 mutation alters L1CAM and TGM2 protein levels
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Solution-phase synthesis of the fluorogenic TGase 2 acyl donor Z-Glu(HMC)-Gly-OH and its use for inhibitor and amine substrate characterisation.
TLDR
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