Transglutaminase 2-mediated activation of β-catenin signaling has a critical role in warfarin-induced vascular calcification.

@article{Beazley2012Transglutaminase2A,
  title={Transglutaminase 2-mediated activation of β-catenin signaling has a critical role in warfarin-induced vascular calcification.},
  author={Kelly E. Beazley and Stephanie C Deasey and Florence Lima and Maria V. Nurminskaya},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2012},
  volume={32 1},
  pages={123-30}
}
OBJECTIVE Accumulating experimental evidence implicates β-catenin signaling and enzyme transglutaminase 2 (TG2) in the progression of vascular calcification, and our previous studies have shown that TG2 can activate β-catenin signaling in vascular smooth muscle cells (VSMCs). Here we investigated the role of the TG2/β-catenin signaling axis in vascular calcification induced by warfarin. METHODS AND RESULTS Warfarin-induced calcification in rat A10 VSMCs is associated with the activation of… CONTINUE READING
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