Transglutaminase 2 is central to induction of the arterial calcification program by smooth muscle cells.

@article{Johnson2008Transglutaminase2I,
  title={Transglutaminase 2 is central to induction of the arterial calcification program by smooth muscle cells.},
  author={Kristen A Johnson and Monika D Polewski and Robert A. Terkeltaub},
  journal={Circulation research},
  year={2008},
  volume={102 5},
  pages={529-37}
}
Arterial calcification is a phenotype of vascular repair in atherosclerosis, diabetes, hyperphosphatemic renal failure, and aging. Arterial calcification is modulated by transition of arterial smooth muscle cells (SMCs) from contractile to chondro-osseous differentiation programmed in response to increases in P(i), bone morphogenetic protein-2, and certain other stimuli. Transglutaminase (TG)2 release modulates tissue repair, partly by transamidation-catalyzed covalent crosslinking of… CONTINUE READING